Can metformin Trigger a High Anion Gap?
Yes, metformin can be associated with a elevated anion gap, but typically indirectly rather than as a common effect. The main issue is metformin-associated lactic acidosis , a uncommon but serious form of high anion gap metabolic acidosis . If metformin presents in the body, it can lead to lactic acidosis , increase lactate , and impair acid-base balance . An Anion Gap Calculator can assist determine whether the pattern of serum electrolytes suggests an acid